Effects of chemical and green nano-zinc oxide on histological changes, oxidative stress, and apoptosis in rat kidney associated with cisplatin

Cisplatin (CP) is used to treat various tumors. A main restriction of cisplatin nephrotoxicity. This study aimed evaluate the protective effects ZnONPs on cisplatin-induced oxidative stress and rat kidney tissue damage. Eighty adult male Wistar rats (250g-270g) were divided into ten groups: Control (CON), Sham (SH), Bulk ZnO (BZnO), Chemical (ChZnONPs), Green (GrZnONPs), (CP), Cisplatin+BulkZnO (CP+BZnO), Cisplatin+Green (CP+GrZnONPs), Cisplatin+Chemical (CP+ChZnONPs), Cisplatin+Explant (CP+EX). CP was i.p administered 5mg/kg/week BZnO, ChZnONPs GrZnONPs at a dose 5mg/kg/day. After 30 days treatment, expression apoptosis/anti apoptosis related genes oxidant/antioxidant factors histological changes in studied. The CP-treated group showed decrease body weight, while Co-administration ZGNPs significant increase compared group. results that increased mRNA level bax, MDA decreased bcl2, SOD CAT activities improved when animals treated with NPs. Our GrZnONPs, BZnO had potential protect against neurotoxicity this effect more evident GrZnONPs.